Methadone
Package of methadone, as a medicine is in syrup and tablets, as well as liquids in capsules. The concentration of the pure substance in medicine 1mg/1ml, 12mg/5ml syrup. Each tablet contains 5 mg of methadone. In the methadone ampoules out there as 1%, 3.5% and 5% solution.
The usual therapeutic oral dose of 5 – 10 mg tablets or solution. Minimum single lethal dose – 40 mg in folks with the development of tolerance to the drug, it increased to 200 mg or more. The action of methadone: In therapeutic doses of methadone has analgesic and sedative effect. It acts on the central nervous system, cardiovascular system and smooth muscle. The initial effects start to be felt after 20-30 minutes after oral administration and comparable to the euphoria as well as the duration of the action of other drugs in opioid group. side effects of methadone are expressed in dizziness, nausea and vomiting, too as sweating. Tolerance to methadone develops slowly. Harm and dependence on methadone. Methadone, like heroin, causes long-term use strong dependence. However, compared with heroin methadone is simpler to produce, costs less and does not need the injection route of administration. Overdose is manifested in respiratory depression, feasible pulmonary edema and acute renal failure. Death of numerous western stars associated with consumption of methadone. Among them – the leader of the rock group Nirvana, Kurt Cobain along with a preferred Playboy model Anna Nicole Smith. Diagnosis and treatment. External signs of methadone are comparable to symptoms of use of other opiates. Typically, a sharp contraction of the pupils, decreased heart rate and insensitivity to physical pain. At the stage of withdrawal symptoms runny nose, chills, nausea, abdominal pain. There are also vomiting, diarrhea and twitching of muscles. Symptoms of chronic methadone dependence: respiratory depression, hyperglycemia, high temperature and pressure, constipation, cramping, bile ducts and stuff.
Today in some countries (like Greece, Spain, Portugal, Italy, France, Sweden, etc.), the medication used to treat patients with heroin addiction, as a substitute means of a gradual reduction in dosage. Treatment generally lasts for a lengthy time with the compulsory use of psychotherapy
However, several neurologists reject replacement therapy mainly because they believe the benefits of replacing one drug by an additional dubious. In addition, weak monitoring of distribution and storage of the drug usually leads to its translation in an illegal turn.
Legislation. In the U.S., methadone is listed in Schedule II. This means that the sale, purchase, or possession with out a prescription is prohibited. Medical institutions, as pain or to treat drug addiction, write methadone. If you are using methadone substitution therapy, the patient is obliged to use the drug within the presence of a physician.
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Good info. Thanks.